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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EDC3
All Species:
18.18
Human Site:
Y225
Identified Species:
36.36
UniProt:
Q96F86
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96F86
NP_001135915.1
508
56078
Y225
V
F
E
E
I
D
T
Y
E
R
R
S
G
T
R
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001097687
287
31155
I35
V
D
Q
V
S
Q
T
I
S
L
T
R
P
F
H
Dog
Lupus familis
XP_867080
508
56081
Y225
V
F
E
E
I
D
T
Y
E
R
R
S
G
T
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8K2D3
508
55939
Y225
V
F
E
E
I
D
T
Y
E
R
R
S
G
S
R
Rat
Rattus norvegicus
XP_001072079
506
55875
Y223
V
F
E
E
I
D
T
Y
E
R
R
S
G
S
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZLS2
506
56018
Y223
V
F
E
E
I
E
T
Y
E
R
R
S
G
T
R
Frog
Xenopus laevis
Q5XH48
505
55557
R222
E
E
I
D
T
H
E
R
R
G
G
G
G
T
R
Zebra Danio
Brachydanio rerio
Q502M5
507
54834
R224
S
Q
I
E
S
S
E
R
R
G
N
G
A
R
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VVI2
680
73397
K369
D
I
E
S
T
T
Q
K
P
D
V
V
R
H
I
Honey Bee
Apis mellifera
XP_392618
616
68864
G340
L
A
L
F
D
K
E
G
M
W
Q
K
I
N
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_787406
618
67525
L335
K
D
N
F
Y
E
E
L
D
A
M
G
D
N
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39998
551
61322
H219
T
Q
S
L
N
I
T
H
L
I
H
S
A
T
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
53.5
96.4
N.A.
95.6
95.8
N.A.
N.A.
88.3
75.1
68.9
N.A.
26.9
30.3
N.A.
35.2
Protein Similarity:
100
N.A.
55.3
98.2
N.A.
97.8
98
N.A.
N.A.
94
85.4
80.3
N.A.
45.2
47
N.A.
51.6
P-Site Identity:
100
N.A.
13.3
100
N.A.
93.3
93.3
N.A.
N.A.
93.3
20
6.6
N.A.
6.6
0
N.A.
6.6
P-Site Similarity:
100
N.A.
20
100
N.A.
100
100
N.A.
N.A.
100
26.6
6.6
N.A.
6.6
13.3
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
39.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
0
0
0
0
0
9
0
0
17
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
17
0
9
9
34
0
0
9
9
0
0
9
0
0
% D
% Glu:
9
9
50
50
0
17
34
0
42
0
0
0
0
0
0
% E
% Phe:
0
42
0
17
0
0
0
0
0
0
0
0
0
9
0
% F
% Gly:
0
0
0
0
0
0
0
9
0
17
9
25
50
0
0
% G
% His:
0
0
0
0
0
9
0
9
0
0
9
0
0
9
9
% H
% Ile:
0
9
17
0
42
9
0
9
0
9
0
0
9
0
9
% I
% Lys:
9
0
0
0
0
9
0
9
0
0
0
9
0
0
0
% K
% Leu:
9
0
9
9
0
0
0
9
9
9
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
9
0
9
0
0
0
0
% M
% Asn:
0
0
9
0
9
0
0
0
0
0
9
0
0
17
9
% N
% Pro:
0
0
0
0
0
0
0
0
9
0
0
0
9
0
0
% P
% Gln:
0
17
9
0
0
9
9
0
0
0
9
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
17
17
42
42
9
9
9
59
% R
% Ser:
9
0
9
9
17
9
0
0
9
0
0
50
0
17
17
% S
% Thr:
9
0
0
0
17
9
59
0
0
0
9
0
0
42
0
% T
% Val:
50
0
0
9
0
0
0
0
0
0
9
9
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% W
% Tyr:
0
0
0
0
9
0
0
42
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _